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ナカジマ レイコ
NAKAJIMA REIKO
中島 怜子 所属 医学部 医学科（東京女子医科大学病院） 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Baseline FDG-PET/CT detects bone marrow involvement in follicular lymphoma and provides relevant prognostic information. |
| 掲載誌名 | 正式名：Blood advances 略 称：Blood Adv ISSNコード：24739537/24739529 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 4(8),pp.1812-1823 |
| 著者・共著者 | Nakajima Reiko, Moskowitz Alison J, Michaud Laure, Mauguen Audrey, Batlevi Connie Lee, Dogan Ahmet, Schöder Heiko |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2020/04 |
| 概要 | In follicular lymphoma (FL), detection of bone marrow (BM) involvement (BMI) by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) improves the accuracy of staging vs BM biopsy (BMB) alone. Our objective was to determine the diagnostic utility of PET for BMI FL and the prognostic value of BMI by PET (positive PET result [PET+]). Records of patients (2002-2016) with PET and BMB at the time of initial treatment were reviewed. BMI was identified by positive BMB result (BMB+) and/or unifocal or multifocal BM FDG uptake on blindly reviewed PET scans with no corresponding CT abnormality (PET+). Among 261 patients, BMI was diagnosed in 78 patients (29.9%) by PET+, in 81 patients (31.0%) by BMB+, and in 113 patients (43.3%) by either PET+ or BMB+. PET+ upstaged 24 patients to stage IV, including 10 from stages I or II to stage IV. Median duration of follow-up was 6.0 years (range, 0-16.6 years). In univariate analysis, a high Follicular Lymphoma International Prognosis Index (FLIPI) score, PET+, and BMB+ correlated with shorter progression-free survival (PFS; all P ≤ .03), and high FLIPI, PET+, and combined PET+ and BMB+ with shorter overall survival (OS; all P ≤ .01). In multivariate analysis, PET+ was the only independent predictor of PFS, whereas high FLIPI score and PET+ predicted OS (P ≤ .03). Combined PET and BMB identify BMI more accurately than either BMB or PET alone, but BMB rarely adds critical information. For patients initiating treatment of FL, identification of BMI by PET is predictive of PFS and OS. |
| DOI | 10.1182/bloodadvances.2020001579 |
| PMID | 32343798 |