NAKAJIMA REIKO
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title The geriatric syndrome of sarcopenia impacts allogeneic hematopoietic cell transplantation outcomes in older lymphoma patients.
Journal Formal name：Leukemia & lymphoma
Abbreviation：Leuk Lymphoma
ISSN code：10292403/10268022
Domestic / ForeginForegin
Volume, Issue, Page pp.1-9
Author and coauthor Lin Richard J, Michaud Laure, Lobaugh Stephanie M, Nakajima Reiko, Mauguen Audrey, Elko Theresa A, Ruiz Josel D, Maloy Molly A, Sauter Craig S, Dahi Parastoo B, Perales Miguel-Angel, Shah Gunjan L, Castillo Flores Nerea, Sanchez-Escamilla Míriam, Tomas Ana Alarcón, San Segundo Lucrecia Yáñez, Cho Christina, Politikos Ioannis, Kim Soo Jung, Korc-Grodzicki Beatriz, Devlin Sean M, Scordo Michael, Schöder Heiko, Giralt Sergio A, Hamlin Paul A
Publication date 2020/03
Summary Older patients with advanced hematologic malignancies are increasingly considered for allogeneic hematopoietic cell transplantation (allo-HCT) yet their survival outcomes remain suboptimal. We and others have previously shown that pre-HCT multi-morbidity and functional limitation and post-HCT geriatric syndromes significantly impact outcomes. Sarcopenia, an accelerated loss of muscle mass and function, has been increasingly recognized in older cancer patients. We identified 146 lymphoma patients 50 years or older who were allografted from 2008 to 2018 at our institution and found that before allo-HCT, 80 (55%) patients were sarcopenic. Pre-HCT sarcopenia was significantly associated with overall survival, progression-free survival, and nonrelapse mortality independent of multi-morbidity and functional limitation. In 6-month landmark analysis, post-HCT sarcopenia remained significantly associated with survival. Our findings illustrate the high prevalence and profound impact of sarcopenia on survival. While requiring prospective confirmation, preemptive, longitudinal, and multidisciplinary interventions for sarcopenia are warranted to improve HCT outcomes for older patients.
DOI 10.1080/10428194.2020.1742909
PMID 32228298