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ナカジマ レイコ
NAKAJIMA REIKO
中島 怜子 所属 医学部 医学科（東京女子医科大学病院） 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 日本語 |
| 査読の有無 | 査読あり |
| 表題 | Evaluation of renal cell carcinoma histological subtype and fuhrman grade using 18F-fluorodeoxyglucose-positron emission tomography/computed tomography. |
| 掲載誌名 | 正式名：European radiology 略 称：Eur Radiol ISSNコード：14321084/09387994 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 27(11),4866-4873頁 |
| 著者・共著者 | Nakajima Reiko, Nozaki Sayumi, Kondo Tsunenori, Nagashima Yoji, Abe Koichiro, Sakai Shuji |
| 担当区分 | 筆頭著者,責任著者 |
| 発行年月 | 2017/11 |
| 概要 | OBJECTIVES:We evaluated 18F-fluorodeoxyglucose (FDG) uptake by renal cell carcinomas (RCCs) to determine whether different histological subtypes and Fuhrman grades can be distinguished.METHODS:We retrospectively reviewed the records and maximum standardised uptake value (SUVmax) of 147 patients with 154 RCCs who underwent FDG-positron emission tomography (PET)/computed tomography (CT) prior to tumour resection.RESULTS:The SUVmax was significantly lower in chromophobe RCC (chRCC) tumours than in clear cell RCC (ccRCC; p = 0.003) and papillary RCC (pRCC; p = 0.034) tumours. The mean tumour SUVmax was 4.58 ± 4.1 (range, 1.29-30.4) for ccRCC, 3.98 ± 1.9 (range, 0.49-6.72) for pRCC, and 1.93 ± 0.9 (range, 0.89-3.41) for chRCC. The SUVmax was not significantly different between the ccRCC and pRCC groups. In ccRCC and pRCC tumours, high-grade tumours had a significantly greater SUVmax (p < 0.001 and p < 0.05) than low-grade tumours by analysis of variance (ANOVA) and the Mann-Whitney U test. In ccRCC, multivariate regression analysis indicated that the SUVmax was a significant indicator of Fuhrman grade. No significant differences in uptake were observed between high- and low-grade chRCC tumours.CONCLUSIONS:The SUVmax obtained using FDG-PET/CT may be an important indicator for predicting tumour grade in ccRCC and pRCC.KEY POINTS:• FDG accumulation reflects tumour aggressiveness and correlates with Fuhrman grade. • FDG-PET/CT enables the differentiation of high- and low-grade ccRCC and pRCCs. • FDG-PET/CT may valuable in the identification of some high-grade RCCs. |
| DOI | 10.1007/s00330-017-4875-z |
| PMID | 28523353 |