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ナカジマ レイコ
NAKAJIMA REIKO
中島 怜子 所属 医学部 医学科（東京女子医科大学病院） 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis on Preoperative 18F-FDG PET/CT in Patients With Renal Cell Carcinoma. |
| 掲載誌名 | 正式名：Clinical nuclear medicine 略 称：Clin Nucl Med ISSNコード：15360229/03639762 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 42(4),pp.e177-e182 |
| 著者・共著者 | Nakajima Reiko, Matsuo Yuka, Kondo Tsunenori, Abe Koichiro, Sakai Shuji |
| 担当区分 | 筆頭著者,責任著者 |
| 発行年月 | 2017/04 |
| 概要 | PURPOSE:We evaluated the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured using pretreatment F-FDG PET/CT in patients with renal cell carcinoma (RCC).METHODS:A total of 139 patients with RCC who had undergone FDG PET/CT before tumor resection were retrospectively reviewed. We determined the SUVmax, MTV, and TLG and compared the results obtained with those required for a progression-free survival (PFS), which was defined as disease progression. Receiver operating characteristic curve analysis was used to compare prediction accuracies. Univariate and multivariate analyses of conventional clinicopathologic variables (age, sex, pathological tumor node metastasis [pTNM] stage, histological type, Fuhrman grade, and presence/absence of microscopic lymphatic and venous invasions) were used to compare the reliability of the metabolic parameters (SUVmax, MTV, and TLG).RESULTS:Of the 139 patients, 24 patients (17%) experienced disease progression during the follow-up period. The age, pTNM stage, Fuhrman grade, presence/absence of microscopic lymphatic and venous invasions, SUVmax, MTV, and TLG were found to be significant prognostic factors for PFS (P < 0.05) on univariate analyses. Multivariate analyses revealed that MTV, TLG, and high pTNM stage (P = 0.02 [hazard ratio, 9.5; 95% confidence interval, 1.50-187.0], P = 0.02 [hazard ratio, 9.0; 95% confidence interval, 1.40-178.5], P = 0.004 [hazard ratio, 5.9; 95% confidence interval, 1.66-20.4], respectively) were the significant predictors after adjustment for other variables of PFS.CONCLUSION:The pretreatment value of MTV, TLG, and high pTNM stage are the significant prognostic factors in patients with RCC. |
| DOI | 10.1097/RLU.0000000000001552 |
| PMID | 28134692 |