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ナカジマ レイコ
NAKAJIMA REIKO
中島 怜子 所属 医学部 医学科（東京女子医科大学病院） 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Optimization of scan initiation timing after 11C-methionine administration for the diagnosis of suspected recurrent brain tumors. |
| 掲載誌名 | 正式名：Annals of nuclear medicine 略 称：Ann Nucl Med ISSNコード：18646433/09147187 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 31(2),pp.190-197 |
| 著者・共著者 | Nakajima Reiko, Abe Koichiro, Momose Mitsuru, Fukushima Kenji, Matsuo Yuka, Kimura Ken, Kondo Chisato, Sakai Shuji |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2017/02 |
| 概要 | OBJECTIVE:11C-Methionine (MET) positron emission tomography (PET) imaging is a valuable technique for the evaluation of primary and recurrent brain tumors. Many studies have used MET-PET for data acquisition starting at 20 min after the tracer injection, while others have used scan initiation times at 5-15 min postinjection. No previous studies have identified the best acquisition timing during MET-PET imaging for suspected recurrent brain tumors. Here we sought to determine the optimal scan initiating timing after MET administration for the detection of recurrent brain tumors.MATERIALS AND METHODS:Twenty-three consecutive patients with suspected recurrent brain tumors underwent MET-PET examinations. Brain PET images were reconstructed from the four serial data sets (10-15, 15-20, 20-25, and 25-30 min postinjection) that were obtained using the list-mode acquisition technique. We determined the maximal standardized uptake values (SUVmax) of the target lesions and the target-to-normal-tissue ratios (TNRs), calculated as the SUVmax to the SUVmean of a region of interest placed on the normal contralateral frontal cortex. Target lesions without significant MET uptake were excluded.RESULTS:Thirty-one lesions from 23 patients were enrolled. There were no significant differences in MET SUVmax or TNR values among the PET images that were reconstructed with the data extracted from the four phases postinjection.CONCLUSION:The MET uptake in the suspected recurrent brain tumors was comparable among all data extraction time phases from 10 to 30 min postinjection. The scan initiation time of MET-PET at 10 min after the injection is allowable for the detection of recurrent brain tumors. The registration identification number of the original study is 1002. |
| DOI | 10.1007/s12149-016-1140-5 |
| PMID | 27885545 |