NAKAJIMA REIKO
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | Clinical role of early dynamic FDG-PET/CT for the evaluation of renal cell carcinoma. |
Journal | Formal name:European radiology Abbreviation:Eur Radiol ISSN code:14321084/09387994 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 26(6),pp.1852-62 |
Author and coauthor | Nakajima Reiko, Abe Koichiro, Kondo Tsunenori, Tanabe Kazunari, Sakai Shuji |
Authorship | Lead author |
Publication date | 2016/06 |
Summary | OBJECTIVES:We studied the usefulness of early dynamic (ED) and whole-body (WB) FDG-PET/CT for the evaluation of renal cell carcinoma (RCC).METHODS:One hundred patients with 107 tumours underwent kidney ED and WB FDG-PET/CT. We visually and semiquantitatively evaluated the FDG accumulation in RCCs in the ED and WB phases, and compared the accumulation values with regard to histological type (clear cell carcinoma [CCC] vs. non-clear cell carcinoma [N-CCC]), the TNM stage (high stage [3-4] vs. low stage [1-2]), the Fuhrman grade (high grade [3-4] vs. low grade [1-2]) and presence versus absence of venous (V) and lymphatic (Ly) invasion.RESULTS:In the ED phase, visual evaluation revealed no significant differences in FDG accumulation in terms of each item. However, the maximum standardized uptake value and tumour-to-normal tissue ratios were significantly higher in the CCCs compared to the N-CCCs (p < 0.001). In the WB phase, in contrast, significantly higher FDG accumulation (p < 0.001) was found in RCCs with a higher TNM stage, higher Furman grade, and the presence of V and Ly invasion in both the visual and the semiquantitative evaluations.CONCLUSIONS:ED and WB FDG-PET/CT is a useful tool for the evaluation of RCCs.KEY POINTS:• ED and WB FDG-PET/ CT helps to assess patients with RCC • ED FDG-PET/CT enabled differentiation between CCC and N-CCC • FDG accumulation in the WB phase reflects tumour aggressiveness • Management of RCC is improved by ED and WB FDG-PET/CT. |
DOI | 10.1007/s00330-015-4026-3 |
PMID | 26403580 |