ナカジマ　レイコ   NAKAJIMA REIKO   中島　怜子    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Clinical role of early dynamic FDG-PET/CT for the evaluation of renal cell carcinoma.
掲載誌名	正式名：European radiology 略　 称：Eur Radiol ISSNコード：14321084/09387994
掲載区分	国外
巻・号・頁	26(6),pp.1852-62
著者・共著者	Nakajima Reiko, Abe Koichiro, Kondo Tsunenori, Tanabe Kazunari, Sakai Shuji
担当区分	筆頭著者
発行年月	2016/06
概要	OBJECTIVES:We studied the usefulness of early dynamic (ED) and whole-body (WB) FDG-PET/CT for the evaluation of renal cell carcinoma (RCC).METHODS:One hundred patients with 107 tumours underwent kidney ED and WB FDG-PET/CT. We visually and semiquantitatively evaluated the FDG accumulation in RCCs in the ED and WB phases, and compared the accumulation values with regard to histological type (clear cell carcinoma [CCC] vs. non-clear cell carcinoma [N-CCC]), the TNM stage (high stage [3-4] vs. low stage [1-2]), the Fuhrman grade (high grade [3-4] vs. low grade [1-2]) and presence versus absence of venous (V) and lymphatic (Ly) invasion.RESULTS:In the ED phase, visual evaluation revealed no significant differences in FDG accumulation in terms of each item. However, the maximum standardized uptake value and tumour-to-normal tissue ratios were significantly higher in the CCCs compared to the N-CCCs (p < 0.001). In the WB phase, in contrast, significantly higher FDG accumulation (p < 0.001) was found in RCCs with a higher TNM stage, higher Furman grade, and the presence of V and Ly invasion in both the visual and the semiquantitative evaluations.CONCLUSIONS:ED and WB FDG-PET/CT is a useful tool for the evaluation of RCCs.KEY POINTS:• ED and WB FDG-PET/ CT helps to assess patients with RCC • ED FDG-PET/CT enabled differentiation between CCC and N-CCC • FDG accumulation in the WB phase reflects tumour aggressiveness • Management of RCC is improved by ED and WB FDG-PET/CT.
DOI	10.1007/s00330-015-4026-3
PMID	26403580