オサキ ヒロノブ
  尾崎 弘展
   所属   医学部 医学科
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Streamlined sensory motor communication through cortical reciprocal connectivity in a visually guided eye movement task.
掲載誌名 正式名:Nature communications
略  称:Nat Commun
ISSNコード:(2041-1723)2041-1723(Linking)
掲載区分国外
巻・号・頁 9(1),338頁
著者・共著者 Itokazu Takahide, Hasegawa Masashi, Kimura Rui, Osaki Hironobu, Albrecht Urban-Raphael, Sohya Kazuhiro, Chakrabarti Shubhodeep, Itoh Hideaki, Ito Tetsufumi, Sato Tatsuo K, Sato Takashi R
発行年月 2018/01
概要 Cortical computation is distributed across multiple areas of the cortex by networks of reciprocal connectivity. However, how such connectivity contributes to the communication between the connected areas is not clear. In this study, we examine the communication between sensory and motor cortices. We develop an eye movement task in mice and combine it with optogenetic suppression and two-photon calcium imaging techniques. We identify a small region in the secondary motor cortex (MOs) that controls eye movements and reciprocally connects with a rostrolateral part of the higher visual areas (VRL/A/AL). These two regions encode both motor signals and visual information; however, the information flow between the regions depends on the direction of the connectivity: motor information is conveyed preferentially from the MOs to the VRL/A/AL, and sensory information is transferred primarily in the opposite direction. We propose that reciprocal connectivity streamlines information flow, enhancing the computational capacity of a distributed network.
DOI 10.1038/s41467-017-02501-4
PMID 29362373