オサキ ヒロノブ
  尾崎 弘展
   所属   医学部 医学科
   職種   助教
論文種別 原著
言語種別 英語
査読の有無 査読あり
表題 Enriched expression of serotonin 1B and 2A receptor genes in macaque visual cortex and their bidirectional modulatory effects on neuronal responses.
掲載誌名 正式名:Cerebral cortex (New York, N.Y. : 1991)
略  称:Cereb Cortex
ISSNコード:1460-2199(Electronic)1047-3211(Linking)
巻・号・頁 19(8),1915-28頁
著者・共著者 Watakabe Akiya, Komatsu Yusuke, Sadakane Osamu, Shimegi Satoshi, Takahata Toru, Higo Noriyuki, Tochitani Shiro, Hashikawa Tsutomu, Naito Tomoyuki, Osaki Hironobu, Sakamoto Hiroshi, Okamoto Masahiro, Ishikawa Ayako, Hara Shin-ichiro, Akasaki Takafumi, Sato Hiromichi, Yamamori Tetsuo
発行年月 2009/08
概要 To study the molecular mechanism how cortical areas are specialized in adult primates, we searched for area-specific genes in macaque monkeys and found striking enrichment of serotonin (5-hydroxytryptamine, 5-HT) 1B receptor mRNA, and to a lesser extent, of 5-HT2A receptor mRNA, in the primary visual area (V1). In situ hybridization analyses revealed that both mRNA species were highly concentrated in the geniculorecipient layers IVA and IVC, where they were coexpressed in the same neurons. Monocular inactivation by tetrodotoxin injection resulted in a strong and rapid (<3 h) downregulation of these mRNAs, suggesting theretinal activity dependency of their expression. Consistent with the high expression level in V1, clear modulatory effects of 5-HT1B and 5-HT2A receptor agonists on the responses of V1 neurons were observed in in vivo electrophysiological experiments. The modulatory effect of the 5-HT1B agonist was dependent on the firing rate of the recorded neurons: The effect tended to be facilitative for neurons with a high firing rate, and suppressive for those with a low firing rate. The 5-HT2A agonist showed opposite effects. These results suggest that this serotonergic system controls the visual response in V1 for optimization of information processing toward the incoming visual inputs.
DOI 10.1093/cercor/bhn219
文献番号 19056862