IIDZUKA Yuzuru    Department   School of Medicine, School of Medicine    Position   Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Effect of Intracerebroventricular Administration of Galanin-Like Peptide on Hepatokines in C57BL/6 J Mice.
Journal	Formal name：Journal of molecular neuroscience : MN Abbreviation：J Mol Neurosci ISSN code：15591166/08958696
Domestic / Foregin	Foregin
Volume, Issue, Page	74(1),pp.25
Author and coauthor	Hirako Satoshi, Wada Nobuhiro, Iizuka Yuzuru, Hirabayashi Takahiro, Kageyama Haruaki, Kim Hyounju, Kaibara Naoko, Yanagisawa Naoko, Takenoya Fumiko, Shioda Seiji
Publication date	2024/02
Summary	Galanin-like peptide (GALP) is a neuropeptide that was first isolated and identified from the porcine hypothalamus. Studies have described an anti-obesity effect of GALP. We previously found that intracerebroventricular administration of GALP in mice resulted in an increase in respiratory exchange rate 12 to 16 h later. GALP may also affect glucose metabolism, but the detailed mechanism has not been elucidated. In this study, we investigated the effects of GALP on glucose and lipid metabolism in the liver. Nine-week-old male C57BL / 6 J mice were administered a single intracerebroventricular dose of saline or GALP and dissected 16 h later. There were no significant between-group differences in body weight and blood glucose levels. With regard to gene and protein expression, G6Pase associated with hepatic gluconeogenesis was significantly reduced in the GALP group. In addition, the hepatokines selenoprotein P and fetuin-A, which induce insulin resistance in the liver, were significantly decreased in the GALP group. These results suggest that intracerebroventricular administration of GALP decreases the expression of key hepatokines, thereby enhancing glucose metabolism.
DOI	10.1007/s12031-024-02200-y
PMID	38386221