IIDZUKA Yuzuru
   Department   School of Medicine, School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Benefits of combination low-dose pioglitazone plus fish oil on aged type 2 diabetes mice.
Journal Formal name:Journal of food and drug analysis
Abbreviation:J Food Drug Anal
ISSN code:10219498
Domestic / ForeginForegin
Volume, Issue, Page 26(4),pp.1265-1274
Author and coauthor Iizuka Yuzuru, Kim Hyounju, Hirako Satoshi, Chiba Kanako, Wada Masahiro, Matsumoto Akiyo
Authorship Lead author
Publication date 2018/10
Summary The elderly patients with type 2 diabetes suffer more adverse drug events than young adults due to pharmacokinetic and pharmacodynamic changes associated with aging. Reducing the risks of these medication-related problems are equally important for the clinical care of older type 2 diabetes patients. Pioglitazone is used for treating type 2 diabetes as an oral antidiabetic drug. Despite pioglitazone is used helpful insulin sensitizers, the accumulation of subcutaneous fat is considered a major adverse effect of pioglitazone therapy. We investigated to reduce the adverse effect of pioglitazone by combination with fish oil rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in aged diabetic KK mice. The accumulation of subcutaneous fat associated with high-dose pioglitazone is reduced by fish oil, suppressing lipogenesis and stimulating fatty acid β-oxidation in the liver. Our data suggest that adding fish oil to low-dose pioglitazone results in antidiabetic efficacy similar to that of the high-dose without concomitant body weight gain.
DOI 10.1016/j.jfda.2018.05.008
PMID 30249325