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論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Benefits of combination low-dose pioglitazone plus fish oil on aged type 2 diabetes mice.
掲載誌名	正式名：Journal of food and drug analysis 略　 称：J Food Drug Anal ISSNコード：10219498
掲載区分	国外
巻・号・頁	26(4),pp.1265-1274
著者・共著者	Iizuka Yuzuru, Kim Hyounju, Hirako Satoshi, Chiba Kanako, Wada Masahiro, Matsumoto Akiyo
担当区分	筆頭著者
発行年月	2018/10
概要	The elderly patients with type 2 diabetes suffer more adverse drug events than young adults due to pharmacokinetic and pharmacodynamic changes associated with aging. Reducing the risks of these medication-related problems are equally important for the clinical care of older type 2 diabetes patients. Pioglitazone is used for treating type 2 diabetes as an oral antidiabetic drug. Despite pioglitazone is used helpful insulin sensitizers, the accumulation of subcutaneous fat is considered a major adverse effect of pioglitazone therapy. We investigated to reduce the adverse effect of pioglitazone by combination with fish oil rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in aged diabetic KK mice. The accumulation of subcutaneous fat associated with high-dose pioglitazone is reduced by fish oil, suppressing lipogenesis and stimulating fatty acid β-oxidation in the liver. Our data suggest that adding fish oil to low-dose pioglitazone results in antidiabetic efficacy similar to that of the high-dose without concomitant body weight gain.
DOI	10.1016/j.jfda.2018.05.008
PMID	30249325