イイヅカ　ユズル   飯塚　讓    所属   医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Effect of Intranasal Administration of Galanin-like Peptide (GALP) on Body Weight and Hepatic Lipids Accumulation in Mice with Diet-induced Obesity.
掲載誌名	正式名：Current pharmaceutical design 略　 称：Curr Pharm Des ISSNコード：18734286/13816128
掲載区分	国外
巻・号・頁	23(25),pp.3751-3756
著者・共著者	Hirako Satoshi, Wada Nobuhiro, Kageyama Haruaki, Takenoya Fumiko, Kim Hyounju, Iizuka Yuzuru, Matsumoto Akiyo, Okabe Mai, Shioda Seiji
発行年月	2017/09
概要	Galanin-like peptide (GALP) is a neuropeptide involved in the regulation of food intake behavior, body weight and energy metabolism. In previous studies, we demonstrated that the intranasal administration of GALP has weight loss effects, although the mechanism of this action was not clarified. The aim of this study was to demonstrate the functional significance of GALP on lipid metabolism in the liver. Mice were fed a high fat diet to cause diet-induced obesity (DIO) and then administered GALP intranasally for 2 weeks (experimental), or vehicle (control). Body weights, along with lipid levels in the plasma and liver, and lipid metabolism-related gene expression in the liver were subsequently measured. Body weight gain was decreased by the GALP treatment compared to the control group. Lipid droplet levels in hepatocytes and hepatic triglyceride levels were decreased in the GALP group compared with the vehicle group, whereas hepatic fatty acid β-oxidation-related gene mRNA levels were increased in the GALP group. These results suggest that the intranasal administration of GALP has an inhibitory effect on lipid accumulation in the liver.
DOI	10.2174/1381612823666170321095950
PMID	28325141