IIDZUKA Yuzuru
   Department   School of Medicine, School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Fish oil prevents excessive hepatic lipid accumulation without inducing oxidative stress.
Journal Formal name:Prostaglandins, leukotrienes, and essential fatty acids
Abbreviation:Prostaglandins Leukot Essent Fatty Acids
ISSN code:15322823/09523278
Domestic / ForeginForegin
Volume, Issue, Page 88(5),pp.365-371
Author and coauthor Hirako Satoshi, Kim Hyoun Ju, Iizuka Yuzuru, Nakasatomi Maki, Matsumoto Akiyo
Publication date 2013/05
Summary We examined the effects of fish oil (FO) on high-cholesterol diet-induced hepatic lipid accumulation and oxidative stress. Female C57BL/6J mice were fed diets consisting of safflower oil (SO), 1 en% FO (1FO), 2 en% FO (2FO), or 20 en% FO (20FO) with or without 2 weight% (wt%) cholesterol (SO/CH, 1FO/CH, 2FO/CH, and 20FO/CH groups, respectively) for 8 weeks. The hepatic triacylglyceride levels were significantly lower in the 2FO/CH and 20FO/CH groups than in the SO/CH group. The hepatic mRNAs of fatty acid oxidation-related genes were upregulated and the fatty acid synthesis-related genes were downregulated by the FO feeding. Adverse effects were not observed in the plasma levels of indicators of oxidative stress in response to the consumption of FO up to 20 en%. These results suggest that FO consumption in the range of 2-20 en% prevents hepatic lipid accumulation, thus improving lipid metabolism without causing oxidative stress.
DOI 10.1016/j.plefa.2013.02.003
PMID 23478025