イイヅカ　ユキ   IZUKA Yuki   飯塚　有希    所属   その他 その他    職種   嘱託医師
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Successful Rituximab Treatment in Thrombotic Thrombocytopenic Purpura Patients Complicated by Other Autoimmune Disorders: Two Case Reports.
掲載誌名	正式名：Internal medicine (Tokyo, Japan) 略　 称：Intern Med ISSNコード：13497235/09182918
掲載区分	国外
巻・号・頁	60(17),pp.2859-2862
著者・共著者	Watanabe Aya†, Shiseki Masayuki, Oishi Megumi, Kobayashi Maya, Oshima Shoko, Osanai Satoko, Ryuzaki Michiko, Izuka Yuki, Tanaka Norina, Ishiyama Midori, Shinohara Akihito, Kazama Hiroshi, Hagiwara Shotaro, Yoshinaga Kentaro, Tanaka Junji
発行年月	2021/09
概要	We herein report two cases of thrombotic thrombocytopenic purpura (TTP) complicated by other autoimmune disorders, autoimmune hepatitis and immune thrombocytopenia, respectively. In both cases, corticosteroids were continuously administered for the treatment of preceding autoimmune disorders. However, a sufficient objective response for TTP was not obtained by plasma exchange and corticosteroid treatment. Once a week rituximab (375 mg/m2) treatment for 4 times was initiated within 2 weeks from the diagnosis. Both patients achieved a sufficient response, and have never had any recurrence as of the last follow-up dates. The early introduction of rituximab could be an effective treatment option in TTP patients complicated with other autoimmune disorders.
DOI	10.2169/internalmedicine.6387-20
PMID	33775998