東　剣虹    Department   Research Institutes and Facilities, Research Institutes and Facilities    Position   Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Extension of chronological lifespan by ScEcl1 depends on mitochondria in Saccharomyces cerevisiae.
Journal	Formal name：Bioscience, biotechnology, and biochemistry Abbreviation：Biosci Biotechnol Biochem ISSN code：(1347-6947)0916-8451(Linking)
Volume, Issue, Page	76(10),pp.1938-42
Author and coauthor	Azuma Kenko, Ohtsuka Hokuto, Murakami Hiroshi, Aiba Hirofumi
Authorship	Lead author
Publication date	2012
Summary	Ecl1, a product of the YGR146C gene in Saccharomyces cerevisiae, was identified as a factor involved in chronological lifespan. In this study we found evidence that the function of Ecl1 in the extension of chronological lifespan is dependent on mitochondrial function. The respiratory activity of cells increased when Ecl1 was overexpressed or cells were grown under calorie restriction, but there was no additive effect of calorie restriction and Ecl1 overexpression on increases in respiratory activity or on the extension of chronological lifespan. Based on these results, we propose that overexpression of Ecl1 has same effect as caloric restriction and that its function also depends on mitochondria, just like caloric restriction.
DOI	10.1271/bbb.120427
PMID	23047113