青山 翔太
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Review article
Language English
Peer review Non peer reviewed
Title Inducible Tertiary Lymphoid Structures: Promise and Challenges for Translating a New Class of Immunotherapy.
Journal Formal name:Frontiers in immunology
Abbreviation:Front Immunol
ISSN code:16643224/16643224
Domestic / ForeginForegin
Volume, Issue, Page 12,pp.675538
Author and coauthor Aoyama Shota, Nakagawa Ryosuke, Mulé James J, Mailloux Adam W
Authorship Lead author
Publication date 2021/05
Summary Tertiary lymphoid structures (TLS) are ectopically formed aggregates of organized lymphocytes and antigen-presenting cells that occur in solid tissues as part of a chronic inflammation response. Sharing structural and functional characteristics with conventional secondary lymphoid organs (SLO) including discrete T cell zones, B cell zones, marginal zones with antigen presenting cells, reticular stromal networks, and high endothelial venues (HEV), TLS are prominent centers of antigen presentation and adaptive immune activation within the periphery. TLS share many signaling axes and leukocyte recruitment schemes with SLO regarding their formation and function. In cancer, their presence confers positive prognostic value across a wide spectrum of indications, spurring interest in their artificial induction as either a new form of immunotherapy, or as a means to augment other cell or immunotherapies. Here, we review approaches for inducible (iTLS) that utilize chemokines, inflammatory factors, or cellular analogues vital to TLS formation and that often mirror conventional SLO organogenesis. This review also addresses biomaterials that have been or might be suitable for iTLS, and discusses remaining challenges facing iTLS manufacturing approaches for clinical translation.
DOI 10.3389/fimmu.2021.675538
PMID 34054863