アオヤマ　シヨウタ   青山　翔太    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	総説
言語種別	英語
査読の有無	査読なし
表題	Inducible Tertiary Lymphoid Structures: Promise and Challenges for Translating a New Class of Immunotherapy.
掲載誌名	正式名：Frontiers in immunology 略　 称：Front Immunol ISSNコード：16643224/16643224
掲載区分	国外
巻・号・頁	12,pp.675538
著者・共著者	Aoyama Shota, Nakagawa Ryosuke, Mulé James J, Mailloux Adam W
担当区分	筆頭著者
発行年月	2021/05
概要	Tertiary lymphoid structures (TLS) are ectopically formed aggregates of organized lymphocytes and antigen-presenting cells that occur in solid tissues as part of a chronic inflammation response. Sharing structural and functional characteristics with conventional secondary lymphoid organs (SLO) including discrete T cell zones, B cell zones, marginal zones with antigen presenting cells, reticular stromal networks, and high endothelial venues (HEV), TLS are prominent centers of antigen presentation and adaptive immune activation within the periphery. TLS share many signaling axes and leukocyte recruitment schemes with SLO regarding their formation and function. In cancer, their presence confers positive prognostic value across a wide spectrum of indications, spurring interest in their artificial induction as either a new form of immunotherapy, or as a means to augment other cell or immunotherapies. Here, we review approaches for inducible (iTLS) that utilize chemokines, inflammatory factors, or cellular analogues vital to TLS formation and that often mirror conventional SLO organogenesis. This review also addresses biomaterials that have been or might be suitable for iTLS, and discusses remaining challenges facing iTLS manufacturing approaches for clinical translation.
DOI	10.3389/fimmu.2021.675538
PMID	34054863