サイトウ　サトシ   斉藤　聡志    所属   医学部 医学科（東京女子医科大学病院）    職種   助教
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Four Cases of Suspected Levetiracetam-Induced Asymptomatic Rhabdomyolysis.
掲載誌名	正式名：Cureus 略　 称：Cureus ISSNコード：21688184/21688184
掲載区分	国外
巻・号・頁	15(7),pp.e41666
著者・共著者	Saito Satoshi, Iijima Mutsumi, Ikeguchi Ryotaro, Ishizuka Kentaro, Kitagawa Kazuo
担当区分	筆頭著者,責任著者
発行年月	2023/07
概要	Rhabdomyolysis is a known side effect of levetiracetam. In general, a patient with rhabdomyolysis complains of muscle pain and swelling. Herein, we report four cases of asymptomatic levetiracetam-induced rhabdomyolysis. In all the four cases, the seizures resolved after more than five days. The patients received continuous fluid replacement from the time they were admitted to our hospital. However, serum creatine kinase (CK) levels continued to rise without symptoms consistent with rhabdomyolysis. The serum CK level improved rapidly when levetiracetam was replaced with lacosamide. Because levetiracetam occasionally causes asymptomatic rhabdomyolysis, routine blood tests should be performed after its initiation.
DOI	10.7759/cureus.41666
PMID	37575737