斉藤 聡志
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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Article types | Case report |
Language | English |
Peer review | Peer reviewed |
Title | Levofloxacin-associated Encephalopathy with Severe Hyperventilation. |
Journal | Formal name:Internal medicine (Tokyo, Japan) Abbreviation:Intern Med ISSN code:13497235/09182918 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 58(10),pp.1495-1499 |
Author and coauthor | Sugiura Mieko, Shibata Koichi, Saito Satoshi, Nishimura Yoshiko, Sakura Hiroshi |
Publication date | 2019/05 |
Summary | A 64-year-old woman with no previous mental illness took a single 500 mg tablet of levofloxacin for cystitis. Two hours later, she developed psychosis with involuntary movement and severe hyperventilation with respiratory alkalosis. Cranial magnetic resonance imaging findings were unremarkable, and an electroencephalogram revealed no epileptiform discharge. Her symptoms improved on the third day after levofloxacin was discontinued. Levofloxacin-associated encephalopathy with psychotic features is a rare adverse event. Disturbance of gamma-aminobutyric acid-ergic (GABAergic) interneurons by levofloxacin may lead to hyperventilation via dysfunction of the brainstem respiratory network. Physicians should be aware of hyperventilation as an additional serious symptom of levofloxacin-associated encephalopathy in acute settings. |
DOI | 10.2169/internalmedicine.1619-18 |
PMID | 30713304 |