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イズハラ ルナ
Luna Izuhara
伊豆原 るな 所属 医学部 医学科 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Generation of a felinized swine endothelial cell line by expression of feline decay-accelerating factor. |
| 掲載誌名 | 正式名：PloS one 略 称：PLoS One ISSNコード：(1932-6203)1932-6203(Linking) |
| 掲載区分 | 国外 |
| 巻・号・頁 | 10(2),pp.e0117682 |
| 著者・共著者 | Izuhara Luna†, Tatsumi Norifumi, Miyagawa Shuji, Iwai Satomi, Watanabe Masahito, Yamanaka Shuichiro, Katsuoka Yuichi, Nagashima Hiroshi, Okano Hirotaka J, Yokoo Takashi |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2015/02 |
| 概要 | Embryonic stem cell research has facilitated the generation of many cell types for the production of tissues and organs for both humans and companion animals. Because ≥30% of pet cats suffer from chronic kidney disease (CKD), xenotransplantation between pigs and cats has been studied. For a successful pig to cat xenotransplant, the immune reaction must be overcome, especially hyperacute rejection. In this study, we isolated the gene for feline decay-accelerating factor (fDAF), an inhibitor of complement proteins, and transfected a swine endothelial cell line with fDAF to "felinize" the pig cells. These fDAF-expressing cells were resistant to feline serum containing anti-pig antibodies, suggesting that felinized pig cells were resistant to hyperacute rejection. Our results suggest that a "felinized" pig kidney can be generated for the treatment of CKD in cats in the future. |
| DOI | 10.1371/journal.pone.0117682 |
| PMID | 25671605 |