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Hiroki Ishihara
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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| Article types | Original article |
| Language | English |
| Peer review | Peer reviewed |
| Title | Evaluation of Preoperative Aspartate Transaminase/Alanine Transaminase Ratio as an Independent Predictive Biomarker in Patients With Metastatic Renal Cell Carcinoma Undergoing Cytoreductive Nephrectomy: A Propensity Score Matching Study. |
| Journal | Formal name：Clinical genitourinary cancer Abbreviation：Clin Genitourin Cancer ISSN code：19380682/15587673 |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 15(5),pp.598-604 |
| Author and coauthor | Ishihara Hiroki, Kondo Tsunenori, Yoshida Kazuhiko, Omae Kenji, Takagi Toshio, Iizuka Junpei, Tanabe Kazunari |
| Authorship | Lead author |
| Publication date | 2017/10 |
| Summary | BACKGROUND:The usefulness of the aspartate transaminase (AST)/alanine transaminase (ALT) ratio (De Ritis ratio) as a predictive biomarker for patients with metastatic renal cell carcinoma (mRCC) undergoing cytoreductive nephrectomy (CN) remains unclear.PATIENTS AND METHODS:The data from 118 patients were retrospectively evaluated. The endpoints were cancer-specific survival (CSS) and overall survival (OS) after CN. We compared these according to the AST/ALT ratio before and after 1:1 propensity score matching. The independent predictors for CSS and OS were also analyzed.RESULTS:The area under the receiver operating characteristic curve was 0.603. The maximum Youden index indicated that the cutoff value for the AST/ALT ratio was 1.24. Before matching, a high AST/ALT ratio was significantly associated with inferior CSS and OS (P < .05 for all). After matching, 34 patients each were allocated to the high and low AST/ALT ratio groups. In the matched cohort, CSS and OS tended to be lower in the high AST/ALT ratio group, although the results were not statistically significant (median CSS, 18.4 months vs. not reached, P = .121; OS, 18.4 months vs. not reached, P = .0957). Furthermore, multivariate analyses revealed that the AST/ALT ratio was an independent predictor for CSS and OS (CSS hazard ratio, 2.17, P = .0472; OS hazard ratio, 2.30, P = .0258).CONCLUSION:The preoperative AST/ALT ratio can be an effective predictive biomarker for CSS and OS in patients with mRCC. |
| DOI | 10.1016/j.clgc.2017.04.011 |
| PMID | 28495053 |