Hiroki Ishihara
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Peer reviewed
Title Effect of Systemic Inflammation on Survival in Patients With Metastatic Renal Cell Carcinoma Receiving Second-line Molecular-targeted Therapy.
Journal Formal name：Clinical genitourinary cancer
Abbreviation：Clin Genitourin Cancer
ISSN code：19380682/15587673
Domestic / ForeginForegin
Volume, Issue, Page 15(4),pp.495-501
Author and coauthor Ishihara Hiroki, Kondo Tsunenori, Yoshida Kazuhiko, Omae Kenji, Takagi Toshio, Iizuka Junpei, Tanabe Kazunari
Authorship Lead author
Publication date 2017/08
Summary BACKGROUND:The role of systemic inflammatory markers, including C-reactive protein (CRP), the neutrophil/lymphocyte ratio (NLR), and the platelet/lymphocyte ratio (PLR), in predicting survival for patients with metastatic renal cell carcinoma receiving second-line molecular-targeted therapy (mTT) after first-line tyrosine kinase inhibitor failure remains unclear. Thus, we investigated the relationship between systemic inflammation and survival in such patients.PATIENTS AND METHODS:Sixty-three patients were evaluated. Progression-free survival (PFS) and overall survival (OS) after second-line mTT initiation were evaluated according to the inflammatory marker levels. In addition, the prognostic factors for survival were examined.RESULTS:The receiver operating characteristic curves for CRP, NLR, and PLR had areas under the curve of 0.779, 0.619, and 0.655, respectively; no significant differences were noted. The corresponding cutoff values were 0.48, 2.53, and 183. Patients with higher CRP (n = 40), NLR (n = 32), and PLR (n = 22) levels had significantly lower PFS and OS than those with lower CRP, NLR, and PLR levels. Multivariate analyses showed that CRP was the sole independent predictor for PFS and OS.CONCLUSION:Systemic inflammation is associated with survival after second-line mTT. In particular, CRP was a strong independent predictive biomarker of prognosis.
DOI 10.1016/j.clgc.2017.01.018
PMID 28363437