SEKI Yasufumi    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Assistant Professor
Article types	Case report
Language	English
Peer review	Peer reviewed
Title	Hormone-replacement Therapy for Hepatopulmonary Syndrome and NASH Associated with Hypopituitarism.
Journal	Formal name：Internal medicine (Tokyo, Japan) Abbreviation：Intern Med ISSN code：13497235/09182918
Volume, Issue, Page	57(12),pp.1741-1745
Author and coauthor	Torii Nobuyuki, Ichihara Atsuhiro, Mizuguchi Yuki, Seki Yasufumi, Hashimoto Etsuko, Tokushige Katsutoshi
Publication date	2018
Summary	The patient was a 23-year-old man who was diagnosed with severe hypoxemia and liver dysfunction after suffering from sudden difficulty breathing. At 2 years of age, he had been diagnosed with hypopituitarism, and had received hormone-replacement until he was 18 years of age. Echocardiography using micro bubbles and pulmonary scintigraphy indicated intrapulmonary shunt and a liver biopsy showed steatohepatitis. He was diagnosed with hepatopulmonary syndrome associated with nonalcoholic steatohepatitis. Hormone-replacement therapy was re-started. After 5 months, a second liver biopsy revealed the amelioration of nonalcoholic steatohepatitis, which improved his respiratory condition. This case suggested that early effective therapy for chronic liver diseases might improve the pathological and clinical conditions of hepatopulmonary syndrome.
DOI	10.2169/internalmedicine.0027-17
PMID	29910217