UEMURA Shuichiro
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Assistant Professor |
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Article types | Original article |
Language | English |
Peer review | Non peer reviewed |
Title | Examination of Prognostic Factors Affecting Long-Term Survival of Patients with Stage 3/4 Gallbladder Cancer without Distant Metastasis. |
Journal | Formal name:Cancers Abbreviation:Cancers (Basel) ISSN code:20726694/20726694 |
Domestic / Foregin | Foregin |
Volume, Issue, Page | 12(8),pp.2073 |
Author and coauthor | HIGUCHI Ryota†, YAZAWA Takehisa, UEMURA Shuichiro, MATSUNAGA Yutaro, OTA Takehiro, ARAIDA Tatsuo, FURUKAWA Toru, YAMAMOTO Masakazu* |
Publication date | 2020/07 |
Summary | In advanced gallbladder cancer (GBC) radical resection, if multiple prognostic factors are present, the outcome may be poor; however, the details remain unclear. To investigate the poor prognostic factors affecting long-term surgical outcome, we examined 157 cases of resected stage 3/4 GBC without distant metastasis between 1985 and 2017. Poor prognostic factors for overall survival and treatment outcomes of a number of predictable preoperative poor prognostic factors were evaluated. The surgical mortality was 4.5%. In multivariate analysis, blood loss, poor histology, liver invasion, and ≥4 regional lymph node metastases (LNMs) were independent prognostic factors for poor surgical outcomes; invasion of the left margin or the entire area of the hepatoduodenal ligament and a Clavien-Dindo classification ≥3 were marginal factors. The analysis identified outcomes of patients with factors that could be predicted preoperatively, such as liver invasion ≥5 mm, invasion of the left margin or the entire area of the hepatoduodenal ligament, and ≥4 regional LNMs. Thus, the five-year overall survival was 54% for zero factors, 34% for one factor, and 4% for two factors (p < 0.05). A poor surgical outcome was likely when two or more factors were predicted preoperatively; therefore, new treatment strategies are required for such patients. |
DOI | 10.3390/cancers12082073 |
PMID | 32726993 |