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樋口 智昭
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Endowed Assistant Professor |
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| Article types | Case report |
| Language | English |
| Peer review | Peer reviewed |
| Title | A case of multicentric Castleman's disease having lung lesion successfully treated with humanized anti-interleukin-6 receptor antibody, tocilizumab. |
| Journal | Formal name：Journal of Korean medical science Abbreviation：J Korean Med Sci ISSN code：(1598-6357)1011-8934(Linking) |
| Domestic / Foregin | Foregin |
| Volume, Issue, Page | 25(9),pp.1364-7 |
| Author and coauthor | Higuchi Tomoaki, Nakanishi Takashi, Takada Kunio, Matsumoto Mitsuyo, Okada Makoto, Horikoshi Hideyuki, Suzuki Kimihiro |
| Publication date | 2010/09 |
| Summary | This report presents the case of a patient demonstrating multicentric Castleman's disease (MCD) with a lung lesion that was successfully treated with an anti-interleukin-6 receptor antibody, tocilizumab in combination with corticosteroid and tacrolimus. A 43-yr-old female with abnormal shadows on a chest X-ray was referred to the hospital for further examination. She was diagnosed as having MCD based on the characteristic pathology of inguinal lymph node, lung lesions, laboratory data, and undifferentiated arthritis. Corticosteroid and rituximab therapy did not fully ameliorate the symptoms; thus, the therapeutic regimen was changed to include tocilizumab, oral corticosteroid and tacrolimus. This regimen resulted in clinical remission and the dose of tocilizumab and corticosteroid could be tapered. Tocilizumab in combination with corticosteroid and tacrolimus may therefore be a beneficial treatment regimen for lung lesions associated with MCD. |
| DOI | 10.3346/jkms.2010.25.9.1364 |
| PMID | 20808682 |