樋口 智昭
Department School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine Position Endowed Assistant Professor |
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Article types | Original article |
Language | English |
Peer review | Peer reviewed |
Title | The relationships between titers of anti-Ro or anti-La as measured by ELISA and salivary production rate with age correction. |
Journal | Formal name:Modern rheumatology Abbreviation:Mod Rheumatol ISSN code:(1439-7595)1439-7595(Linking) |
Volume, Issue, Page | 18(6),pp.578-84 |
Author and coauthor | Takada Kunio, Suzuki Kimihiro, Matsumoto Mitsuyo, Okada Makoto, Nakanishi Takashi, Horikoshi Hideyuki, Higuchi Tomoaki, Nakayama Akiyoshi, Ohsuzu Fumitaka |
Publication date | 2008 |
Summary | The objective of this work was to clarify the clinical significance of titers of anti-Ro and anti-La, the relationships between titers of either anti-Ro or anti-La, and salivary production rate (SPR). These autoantibodies were titrated using enzyme-linked immunosorbent assay. The Saxon test was performed to measure SPR. Fifty-one females who had anti-Ro but not anticentromere antibodies or anti-U1RNP were enrolled. SPR decreased significantly with age. In order to exclude the effect of aging on SPR, we calculated the "SPR with age correction." According to the results of a multiple regression analysis, only the anti-La titer was significantly associated with SPR with age correction. The distribution pattern of the anti-La titers consisted of two subgroups (with a titer index cutoff of 100.0): a negative anti-La titer (anti-La<25.0) and low anti-La titer (25.0<or=anti-La<100.0) group, and a high anti-La titer group (anti-La>or=100.0). The concentration of serum IgG and the frequency of Sjögren's syndrome in the high anti-La titer group were significantly higher than those in the negative anti-La and low anti-La titer group. Several new aspects of the clinical significance of titrating anti-Ro and anti-La in comparison with SPR have been revealed. |
DOI | 10.1007/s10165-008-0098-0 |
PMID | 18636224 |