樋口　智昭    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Endowed Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Primary biliary cirrhosis in female subjects with sicca-associated antibodies.
Journal	Formal name：Modern rheumatology Abbreviation：Mod Rheumatol ISSN code：(1439-7595)1439-7595(Linking)
Volume, Issue, Page	17(6),pp.486-91
Author and coauthor	Takada Kunio, Suzuki Kimihiro, Matsumoto Mitsuyo, Okada Makoto, Nakanishi Takashi, Horikoshi Hideyuki, Higuchi Tomoaki, Ohsuzu Fumitaka
Publication date	2007
Summary	The aim of this study is to clarify the time course of primary biliary cirrhosis (PBC) in subjects possessing anticentromere antibodies (ACA), anti-Ro, and/or anti-La antibodies, and who used alkaline phosphatase (ALP) as a serological marker for PBC. Female subjects (n = 165), who had at least one of ACA, anti-Ro, and/or anti-La, were enrolled in this study. Groups A (ACA alone, n = 44), B (anti-Ro alone, n = 54), E (anti-Ro and anti-La, n = 52), and DFG (ACA with anti-Ro and/or anti-La, n = 14) were analyzed. Healthy females (n = 65) were used as a control. The frequencies of the PBC in groups A (13.6%) and DFG (14.3%) were higher than those in groups B (1.9%) and E (0.0%). The ALP levels increased with age in groups A and DFG and slightly increased with age in groups B and C, and the control group. After correcting for age by analysis of covariance, a comparison of ALP levels among the groups not having anti-M(2) was as follows: group A falling dots group DFG > group B falling dots group E falling dots the control group. The subjects with ACA might thus have PBC more frequently than either those with anti-Ro and/or anti-La, or the control subjects.
DOI	10.1007/s10165-007-0631-6
PMID	18084701