|
シイハラ マサヒロ
椎原 正尋 所属 医学部 医学科（東京女子医科大学病院） 職種 助教 |
|
| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Comparison of Clinicopathological Features of Biliary Neuroendocrine Carcinoma with Adenocarcinoma. |
| 掲載誌名 | 正式名：Digestive surgery 略 称：Dig Surg ISSNコード：14219883/02534886 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 38(1),pp.30-37 |
| 著者・共著者 | SHIIHARA Kimihiro, HIGUCHI Ryota, FURUKAWA Toru, YAZAWA Takehisa, UEMURA Shuichiro, IZUMO Wataru, YAMAMOTO Masakazu |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2021/01 |
| 概要 | OBJECTIVE:This study aimed to demonstrate the clinical features and postoperative outcomes of extrahepatic bile duct (EHBD) neuroendocrine carcinoma (NEC) and compared with those of adenocarcinoma.METHODS:We retrospectively analyzed patients with EHBD cancer operated in our institution between 1995 and 2015.RESULTS:Of 475 patients, 468 had adenocarcinoma, while 7 had NEC/mixed adenoneuroendocrine carcinoma (MANEC) in this study. There were no notable preoperative and pathological features in patients with NEC/MANEC. However, patients with NEC/MANEC had a higher recurrence rate (51.8 vs. 100%, p = 0.016), poorer relapse-free survival (RFS) time (the median RFS time: 35 vs. 12 months, p = 0.006), and poorer overall survival (OS) time (the median OS time: 60 vs. 19 months, p = 0.078) than those with adenocarcinoma. Furthermore, patients with NEC/MANEC had higher rates of liver metastasis (11.9 vs. 85.7%, p < 0.001) than those with adenocarcinoma. In multivariable regression analysis, pathological type with NEC/MANEC was a risk factor for poorer RFS (p = 0.022, hazard ratio: 6.09).CONCLUSIONS:Patients with NEC/MANEC have high malignant potential and poor outcomes. It is necessary to develop an effective approach and postoperative adjuvant treatment for patients with NEC/MANEC. |
| DOI | 10.1159/000508443 |
| PMID | 32570243 |