大澤　重仁    Department   Research Institutes and Facilities, Research Institutes and Facilities    Position
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Low-adhesion and low-swelling hydrogel based on alginate and carbonated water to prevent temporary dilation of wound sites
Journal	Formal name：International journal of biological macromolecules Abbreviation：Int J Biol Macromol ISSN code：01418130/18790003
Domestic / Foregin	Foregin
Publisher	Elsevier
Volume, Issue, Page	254(3),pp.127928
Author and coauthor	Teshima Ryota†*, Osawa Shigehito, Yoshikawa Miki, Kawano Yayoi*, Otsuka Hidenori, Hanawa Takehisa*
Authorship	2nd author
Publication date	2024/01
Summary	Hydrogel-based wound dressings have been developed for rapid wound healing; however, their adhesive properties have not been adequately investigated. Excessive adhesion to the skin causes wound expansion and pain when hydrogels absorb exudates and swell at wound sites. Herein, we developed a low-adhesion and low-swelling hydrogel dressing using alginate, which is non-adhesive to cells and skin tissue, CaCO3, and carbonated water. The alginate/CaCO3 solution rapidly formed a hydrogel upon the addition of carbonated water, and the CO2 in the hydrogel diffused into the atmosphere, preventing acidification and obtaining a pH value suitable for wound healing. Remarkably, the skin adhesion and swelling of the hydrogel were 11.9- to 16.5-fold and 1.9-fold lower, respectively, than those of clinical low-adhesion hydrogel dressings. In vivo wound-healing tests in mice demonstrated its therapeutic efficacy, and the prepared hydrogel prevented temporary wound dilation during early healing. These results illustrate the importance of controlling skin adhesion and swelling in wound dressings and demonstrate the potential clinical applications of this wound-friendly hydrogel dressing.
DOI	10.1016/j.ijbiomac.2023.127928