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タカダ タクマ
TAKADA Takuma
髙田 卓磨 所属 研究施設 研究施設 職種 助教 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Neoatherosclerosis 5 Years After Bioresorbable Vascular Scaffold Implantation. |
| 掲載誌名 | 正式名：Journal of the American College of Cardiology 略 称：J Am Coll Cardiol ISSNコード：15583597/07351097 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 71(17),pp.1882-1893 |
| 著者・共著者 | Moriyama Noriaki, Shishido Koki, Tanaka Yutaka, Yokota Shohei, Hayashi Takahiro, Miyashita Hirokazu, Koike Tatsuya, Yokoyama Hiroaki, Takada Takuma, Nishimoto Takashi, Ochiai Tomoki, Tobita Kazuki, Yamanaka Futoshi, Mizuno Shingo, Murakami Masato, Takahashi Saeko, Saito Shigeru |
| 発行年月 | 2018/05 |
| 概要 | BACKGROUND:Data regarding neoatherosclerosis after everolimus-eluting bioresorbable vascular scaffold (BVS) (ABSORB BVS Rev. 1.1, Abbott Vascular, Santa Clara, California) implantation are limited.OBJECTIVES:This study investigated the findings of neoatherosclerosis at 5 years after BVS 1.1 implantation by using multi-imaging modalities, including optical coherence tomography (OCT).METHODS:Patients included in the ABSORB EXTEND (ABSORB EXTEND Clinical Investigation) trial at Shonan Kamakura General Hospital underwent OCT at baseline after the index procedure and at 1 and 5 years. Intimal plaque distributions in the in-scaffold and out-scaffold segments were analyzed.RESULTS:Twenty patients (22 lesions) with stable angina pectoris were enrolled. The median follow-up duration was 67 months (interquartile range: 65 to 69 months), and the mean age was 69 ± 8 years. Patients with diabetes mellitus (25%) were included. Based on the baseline angiogram, 10 (46%) lesions were type B2/C lesions. At 1 and 5 years of follow-up, significant differences in the prevalence of in-scaffold lipid-laden neointima (17% vs. 61%; p = 0.04), calcification (28% vs. 94%; p < 0.01), neovascularization (6% vs. 78%; p < 0.01), and thin-cap fibroatheroma (0% vs. 22%; p = 0.02) were found. In the out-scaffold segments, no significant difference in the plaque prevalence between 1 and 5 years was noted.CONCLUSIONS:The occurrence and progression of in-scaffold neoatherosclerosis with luminal narrowing was observed at 5 years after BVS 1.1 implantation. The small size of the current study warrants confirmation in larger study. (ABSORB EXTEND Clinical Investigation [ABSORB EXTEND]; NCT01023789). |
| DOI | 10.1016/j.jacc.2018.02.051 |
| PMID | 29699614 |