KUSUDA Kaori    Department   Research Institutes and Facilities, Research Institutes and Facilities    Position
Article types	Review article
Language	English
Peer review	Peer reviewed
Presence of invitation	Invited paper
Title	Current Landscape of Sonodynamic Therapy for Treating Cancer.
Journal	Formal name：Cancers Abbreviation：Cancers (Basel) ISSN code：20726694/20726694
Domestic / Foregin	Foregin
Volume, Issue, Page	13(24),pp.6184
International coauthorship	International coauthorship
Author and coauthor	YAMAGUCHI Toshihiro†, KITAHARA Shuji, KUSUDA Kaori, OKAMOTO Jun, HORISE Yuki, MASAMUNE Ken, MURAGAKI Yoshihiro*
Publication date	2021/12/08
Summary	Recent advancements have tangibly changed the cancer treatment landscape. However, curative therapy for this dreadful disease remains an unmet need. Sonodynamic therapy (SDT) is a minimally invasive anti-cancer therapy involving a chemical sonosensitizer and focused ultrasound. A high-intensity focused ultrasound (HIFU) beam is used to destroy or denature targeted cancer tissues. Some SDTs are based on unfocused ultrasound (US). In some SDTs, HIFU is combined with a drug, known as a chemical sonosensitizer, to amplify the drug's ability to damage cancer cells preferentially. The mechanism by which US interferes with cancer cell function is further amplified by applying acoustic sensitizers. Combining multiple chemical sonosensitizers with US creates a substantial synergistic effect that could effectively disrupt tumorigenic growth, induce cell death, and elicit an immune response. Therefore, the minimally invasive SDT treatment is currently attracting attention. It can be combined with targeted therapy (double-targeting cancer therapy) and immunotherapy in the future and is expected to be a boon for treating previously incurable cancers. In this paper, we will consider the current state of this therapy and discuss parts of our research.
DOI	10.3390/cancers13246184
PMID	34944804