SAGAWA Takaomi
   Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine
   Position   Assistant Professor
Article types Original article
Language English
Peer review Non peer reviewed
Title Prevalence of fatty liver disease after liver transplantation and risk factors for recipients and donors.
Journal Formal name:Annals of hepatology
Abbreviation:Ann Hepatol
ISSN code:16652681/16652681
Domestic / ForeginForegin
Volume, Issue, Page 27(2),pp.100670
Author and coauthor HORIUCHI Kentaro, KOGISO Tomomi*, SAGAWA Takaomi, TANIAI Makiko, KOTERA Yoshihito, EGAWA Hiroto, TOKUSHIGE Katsutoshi
Publication date 2022
Summary INTRODUCTION AND OBJECTIVES:Fatty liver disease (FLD) may develop in liver transplant recipients. We investigated the recipient and donor risk factors for FLD development after liver transplantation (LT).METHODS:A total of 108 liver transplant recipients (54 men [50.0%]; median age, 52 [20-68] years) treated from 2011-2020 was enrolled. Three recipients died at < 3 months as a result of infection or blood flow impairment, and were excluded from the long-term FLD study. On evaluation of 88 prospective living donors, fatty liver was observed in 21. The prevalence and risk factors for FLD and survival were evaluated.RESULTS:After LT, 28 of 105 recipients (26.7%) developed FLD. FLD was more common in patients with a high body mass index (BMI) and dyslipidemia (both p < 0.01), primary nonalcoholic steatohepatitis (p = 0.02), after living-donor LT (p = 0.03) and everolimus (EVL) use (p = 0.08). Factors predictive of FLD included EVL use and a high BMI (hazard ratios = 3.00 and 1.34; p = 0.05 and p < 0.01, respectively). Sixteen donors lost 6.5 kg (range: 2.0-16.0 kg) of body weight prior to LT. However, there were no cases of primary non-function, which did not affect the FLD prevalence. Development of FLD did not have a negative impact on LT outcome; the 5-year survival rate was 92.6%.CONCLUSIONS:Recipient factors were more important than donor factors for FLD onset after LT.
DOI 10.1016/j.aohep.2022.100670
PMID 35051631