長内　聡子    Department   School of Medicine(Tokyo Women's Medical University Hospital), School of Medicine    Position   Assistant Professor
Article types	Original article
Language	English
Peer review	Peer reviewed
Title	Expression analysis of genes located within the common deleted region of del(20q) in patients with myelodysplastic syndromes.
Journal	Formal name：Leukemia research Abbreviation：Leuk Res ISSN code：18735835/01452126
Domestic / Foregin	Foregin
Volume, Issue, Page	84,pp.106175
Author and coauthor	Shiseki Masayuki†*, Ishii Mayuko, Okada Michiko, Ohwashi Mari, Wang Yan-Hua, Osanai Satoko, Yoshinaga Kentaro, Mori Naoki, Motoji Toshiko, Tanaka Junji
Publication date	2019/09
Summary	Deletion of the long arm of chromosome 20 (del(20q)) is observed in 5-10% of patients with myelodysplastic syndromes (MDS). We examined the expression of 28 genes within the common deleted region (CDR) of del(20q), which we previously determined by a CGH array using clinical samples, in 48 MDS patients with (n = 28) or without (n = 20) chromosome 20 abnormalities and control subjects (n = 10). The expression level of 8 of 28 genes was significantly reduced in MDS patients with chromosome 20 abnormalities compared to that of control subjects. In addition, the expression of BCAS4, ADA, and YWHAB genes was significantly reduced in MDS patients without chromosome 20 abnormalities, which suggests that these three genes were commonly involved in the molecular pathogenesis of MDS. To evaluate the clinical significance, we analyzed the impact of the expression level of each gene on overall survival (OS). According to the Cox proportional hazard model, multivariate analysis indicated that reduced BCAS4 expression was associated with inferior OS, but the difference was not significant (HR, 3.77; 95% CI, 0.995-17.17; P = 0.0509). Functional analyses are needed to understand the biological significance of reduced expression of these genes in the pathogenesis of MDS.
DOI	10.1016/j.leukres.2019.106175
PMID	31299412