マルヤマ　タクマ   丸山　拓真    所属   医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Effects of Progesterone and Other Gonadal Hormones on Glutamatergic Circuits in the Retina.
掲載誌名	正式名：Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 略　 称：J Nippon Med Sch ISSNコード：13473409/13454676
巻・号・頁	90(4),pp.333-345
著者・共著者	Ohkuma Mahito, Maruyama Takuma, Ishii Toshiyuki, Igarashi Nozomi, Azuma Keiko, Inoue Tatsuya, Obata Ryo, Miyachi Ei-Ichi, Kaneda Makoto
発行年月	2023
概要	BACKGROUND:Gonadal hormones function in the retina; however, their targets have not yet been identified. Therefore, the present study examined the effects of progesterone and other gonadal hormones on glutamatergic circuits in the retina.METHODS:Extracellular glutamate concentrations, which correspond to the amount of glutamate released, were examined using an enzyme-linked fluorescent assay system. The activity of glutamatergic synapses between bipolar cells and ganglion cells was investigated using a patch clamp technique. Changes in retinal thickness during pregnancy were assessed using optical coherence tomography (OCT) images.RESULTS:Progesterone and pregnenolone sulfate increased extracellular glutamate concentrations, whereas estrogen and testosterone did not. Progesterone increased the activity of glutamatergic synapses between bipolar cells and ganglion cells. A temporal decrease in the thickness of the peripheral retina was observed in the 1st trimester.CONCLUSIONS:Progesterone, but not estrogen or testosterone, activated glutamate release in the mouse retina. Increases in the concentration of progesterone during pregnancy did not induce any detectable change in retinal thickness.
DOI	10.1272/jnms.JNMS.2023_90-405
PMID	37690823