マルヤマ タクマ
丸山 拓真 所属 医学部 医学科 職種 助教 |
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論文種別 | 原著 |
言語種別 | 英語 |
査読の有無 | 査読あり |
表題 | Alteration of global protein SUMOylation in neurons and astrocytes in response to Alzheimer's disease-associated insults. |
掲載誌名 | 正式名:Biochemical and biophysical research communications 略 称:Biochem Biophys Res Commun ISSNコード:10902104/0006291X |
巻・号・頁 | 500(2),pp.470-475 |
著者・共著者 | Maruyama Takuma, Wada Harmony, Abe Yoichiro, Niikura Takako |
発行年月 | 2018/06 |
概要 | SUMOylation, a post-translational modification of lysine residues by small ubiquitin-like modifier (SUMO) proteins, has been implicated in the pathogenesis of neurodegenerative disorders including Alzheimer's disease (AD), and in neuron- and astrocyte-specific physiological functions. Global SUMOylation is increased in the AD mouse brain in the pre-plaque-forming stage but returns to wild-type levels in the plaque-bearing stage. To clarify the reason for the transient change in SUMOylation, we analyzed the alteration of global SUMOylation induced by AD-associated cytotoxic stimuli in neurons and astrocytes individually. In neurons, amyloid β42 oligomers induced some but not significant increase in levels of SUMO1-modified proteins. Both hydrogen peroxide and glutamate significantly reduced SUMO1-modified protein levels. These changes were more prominent in neurons than in astrocytes. The opposite effect of Aβ and oxidative/excitotoxic stimuli on SUMO1 modification may cause the pathological stage-associated change in the level of SUMO-modified proteins in the AD mouse brain. |
DOI | 10.1016/j.bbrc.2018.04.104 |
PMID | 29660340 |