マルヤマ　タクマ   丸山　拓真    所属   医学部 医学科    職種   助教
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Humanin ameliorates diazepam-induced memory deficit in mice.
掲載誌名	正式名：Neuropeptides 略　 称：Neuropeptides ISSNコード：15322785/01434179
巻・号・頁	62,pp.65-70
著者・共著者	Murakami Minetaka, Nagahama Masatoshi, Maruyama Takuma, Niikura Takako
発行年月	2017/04
概要	Humanin (HN) is an endogenous 24-residue peptide. A highly potent HN derivative, S14G-HN, which has a substitution of serine 14 to glycine, reduced amyloid burden and suppressed cognitive impairment in a mouse model of Alzheimer's disease. S14G-HN also suppressed amnesia induced by a muscarinic receptor antagonist in rodents. To understand the effects of HN on brain function, we tested the effect of S14G-HN on diazepam (DZP)-induced memory impairment and anxiety in mice using the object recognition test and zero-maze test, respectively. Intraperitoneal injection of S14G-HN reversed the DZP-induced memory deficit, whereas no significant change was observed in behavioral markers of anxiety. S14G-HN had no effect on locomotor activity in either test, indicating that S14G-HN did not affect physical functioning or motivation. These results suggest that HN preferentially influences cognitive function but not emotional function in the central nervous system.
DOI	10.1016/j.npep.2016.10.008
PMID	27814910