ワカバヤシ　ヒデタカ   WAKABAYASHI Hidetaka   若林　秀隆    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Dysphagia, Oral Health Burden, and Stool-Detected Oral-Associated Taxa in Older Inpatients After Stroke: A Cross-Sectional Study.
掲載誌名	正式名：Clinical nutrition ESPEN 略　 称：Clin Nutr ESPEN ISSNコード：24054577/24054577
掲載区分	国外
巻・号・頁	pp.105190
著者・共著者	Yoshihiro Yoshimura, Ayaka Matsumoto, Kouki Yoneda, Hidetaka Wakabayashi, Keisuke Maeda
発行年月	2026/10
概要	BACKGROUND & AIMS:Swallowing and oral intake limitations and poor oral health may accompany altered stool microbial profiles after stroke. We examined their associations with a stool-detected oral-associated taxa profile in older inpatients.METHODS:This registry-based cross-sectional analysis included 156 inpatients aged ≥65 years. Swallowing/oral intake status and oral health were assessed using the Food Intake Level Scale (FILS) and Revised Oral Assessment Guide (ROAG). The outcome was a study-defined, standardized six-genera stool-detected oral-associated taxa score. Linear regression used HC3 robust standard errors and clinical covariates. FILS < 7 was the primary exposure; continuous FILS and ROAG were secondary exposures. Additional sensitivity analyses addressed score construction, ordinal FILS, nutritional exposure, missingness, and model diagnostics.RESULTS:Participants had a mean age of 78.4 years; 55.8% were men, and 25 (16.0%) had FILS < 7. In separately adjusted models, the score was lower with FILS < 7 (β -0.99; 95% CI -1.34 to -0.63), higher per FILS point (β 0.15; 95% CI 0.10-0.20), and lower with each 1-SD increase in ROAG (β -0.32; 95% CI -0.45 to -0.18; all p < 0.001). In the joint model, ROAG was attenuated (β -0.13; 95% CI -0.30 to 0.03; p = 0.111), whereas FILS remained associated. The primary association persisted after energy/protein adjustment and diagnostic checks.CONCLUSIONS:Poorer swallowing/oral intake status and greater oral health burden were each associated with a lower stool-detected oral-associated taxa profile in separately adjusted models. The exploratory findings do not establish independent oral-health effects, oral origin, causality, or clinical utility.
DOI	10.1016/j.clnesp.2026.105190
PMID	42854972