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ワカバヤシ ヒデタカ
WAKABAYASHI Hidetaka
若林 秀隆 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Prognostic performance of Asian Working Group for Sarcopenia 2025 Constructs for activities of daily living at discharge after stroke: a head-to-head validation. |
| 掲載誌名 | 正式名：European geriatric medicine 略 称：Eur Geriatr Med ISSNコード：18787649/18787649 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 17(4),pp.2187-2196 |
| 著者・共著者 | Yoshihiro Yoshimura, Hidetaka Wakabayashi, Ayaka Matsumoto, Fumihiko Nagano, Sayuri Shimazu, Kouki Yoneda |
| 担当区分 | 2nd著者 |
| 発行年月 | 2026/08 |
| 概要 | PURPOSE:To compare the prognostic performance of the Asian Working Group for Sarcopenia (AWGS) 2025 diagnostic constructs-specifically height- versus body mass index (BMI)-indexed muscle mass-for discriminating functional outcomes in patients with stroke.METHODS:From a cohort of 1246 consecutive post-acute stroke admissions, we analyzed 864 inpatients (median age 76 years; 47.2% women) who met the inclusion criteria. Sarcopenia was classified according to AWGS 2025 criteria: possible sarcopenia (low handgrip strength) and confirmed sarcopenia (low strength plus low skeletal muscle mass). Skeletal muscle mass was indexed by height-squared (SMI/height2) and BMI (SMI/BMI). Multivariable linear regression analysis, stratified by age (50-64 vs. ≥ 65 years) and sex, assessed the associations with the Functional Independence Measure motor subscale (FIM-motor) at discharge.RESULTS:Confirmed sarcopenia defined by SMI/height2 was independently and consistently associated with lower discharge FIM-motor scores across all age and sex strata (men ≥ 65 years: B - 3.51, P = 0.038; women ≥ 65 years: B - 3.08, P = 0.024; men 50-64 years: B - 4.59, P = 0.044; women 50-64 years: B - 9.19, P = 0.045). In contrast, SMI/BMI-based definitions showed poor prognostic utility, with no significant associations in men. Possible sarcopenia demonstrated limited, inconsistent associations.CONCLUSION:AWGS 2025 confirmed sarcopenia utilizing height-indexed muscle mass provided superior prognostic discrimination for discharge ADL compared with BMI-indexed or possible sarcopenia constructs in post-stroke inpatients. These findings support prioritizing height-indexed confirmed sarcopenia for functional risk stratification in this setting. |
| DOI | 10.1007/s41999-026-01554-3 |
| PMID | 42412390 |