ヒラノ　ハジメ   HIRANO Hajime   平野　一    所属   医学部 医学科（東京女子医科大学病院）    職種   准教授
論文種別	原著
言語種別	英語
査読の有無	査読なし
表題	Safety and Efficacy of Selective Plasma Exchange Versus Conventional Plasma Exchange in Pretransplant Desensitization of ABO-Incompatible Kidney Transplantation.
掲載誌名	正式名：Journal of clinical apheresis 略　 称：J Clin Apher ISSNコード：10981101/07332459
掲載区分	国外
巻・号・頁	41(5),pp.e70186
著者・共著者	Inoue Takahiro, Hirano Hajime, Munakata Yu, Kawaguchi Yuki, Tsuchiya Ken, Unagami Kohei, Hoshino Junichi, Ishida Hideki, Takagi Toshio, Hanafusa Norio
担当区分	2nd著者
発行年月	2026/10
概要	Selective plasma exchange (SePE) may reduce adverse events associated with fresh frozen plasma (FFP) use during pretransplant desensitization for ABO-incompatible kidney transplantation. We conducted a single-center retrospective cohort study of 75 patients who underwent ABO-incompatible kidney transplantation between January 2020 and April 2024. Of these, 48 received SePE and 27 received conventional plasma exchange (CPE) with FFP. We compared antibody titers at transplantation, perioperative outcomes, and procedure-related adverse events between the groups. Adverse events occurred in 5 patients (10.4%) in the SePE group and 17 patients (63.0%) in the CPE group (p < 0.001). Anaphylactic shock occurred in no patients in the SePE group and 4 patients (14.8%) in the CPE group (p = 0.027). All patients in the SePE group and all but one patient in the CPE group achieved the prespecified preoperative antibody titer target of ≤ 1:32. Neither surgical operating time nor intraoperative blood loss differed significantly between the groups. In this cohort, SePE was associated with fewer procedure-related adverse events than CPE with FFP while achieving the preoperative antibody titer target in all SePE-treated patients.
DOI	10.1002/jca.70186
PMID	42834343