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ホンダ ゴロウ
HONDA Gorou
本田 五郎 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Surgical Resection for Colorectal Liver Metastasis in Elderly Patients Aged ≥ 80: A Retrospective Nationwide Cohort Survey in Japan With Propensity Score Matching |
| 掲載誌名 | 正式名：Annals of gastroenterological surgery 略 称：Ann Gastroenterol Surg ISSNコード：24750328/24750328 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 10(4),pp.1107-1119 |
| 著者・共著者 | SUGIMOTO Kiichi,SAIURA Akio,NOJIRI Shuko,KOBAYASHI Hirotoshi,HONDA Goro,KAWAI Kazushige,HASEGAWA Kiyoshi,TAKAHASHI Keiichi |
| 発行年月 | 2026/07 |
| 概要 | BACKGROUND:As the aging of the global population increases, the number of elderly patients with colorectal liver metastasis (CRLM) is expected to increase. The aim of this study was to clarify the long-term oncological outcomes and treatment of CRLM in elderly patients aged ≥ 80.METHODS:Patients with CRLM were identified from the Japanese database of Liver Metastases Survey of Colorectal Cancer, collected from 145 centers. Two thousand four hundred nine patients with liver resection were eligible for analysis. This cohort was divided into two groups aged < 80 (group Y (younger); n = 2194) and ≥ 80 (group E (elderly); n = 215). We compared the long-term outcomes after liver resection of patients with CRLM aged ≥ 80 and < 80 years after adjustment using propensity score matching (PSM), and we identified the reasons for differences in these outcomes.RESULTS:After PSM, group E showed a comparable recurrence-free survival to that in group Y (hazard ratio (HR): 1.20, p = 0.16). However, group E had significantly worse cancer-specific survival (CSS) (HR: 1.77, p = 0.002) and overall survival (OS) (HR: 1.80, p = 0.0004). Treatment for recurrence was given at a significantly lower rate in group E (80/130 (61.5%) vs. 1148/1329 (86.4%), p < 0.0001).CONCLUSIONS:Surgical resection seems to be as effective in elderly patients aged ≥ 80 as in nonelderly patients. The significantly worse CSS and OS may have resulted from a lower rate of treatment for recurrence in elderly patients aged ≥ 80. Physicians should keep this finding in mind with regard to limitations of treatments for recurrence after initial liver resection in elderly patients aged ≥ 80 with CRLM. |
| DOI | 10.1002/ags3.70213 |
| PMID | 42395149 |