ナカバヤシ　アキラ   NAKABAYASHI Akira   中林　章    所属   医学部 医学科（附属足立医療センター）    職種   教授
論文種別	症例報告
言語種別	英語
査読の有無	査読あり
表題	Lymphoepithelioma-like carcinoma of the uterine cervix: A case report with cytological findings.
掲載誌名	正式名：Molecular and clinical oncology 略　 称：Mol Clin Oncol ISSNコード：20499469/20499450
掲載区分	国外
巻・号・頁	23(5),pp.97
著者・共著者	Yoshika Akizawa, Akira Nakabayashi, Kaoruko Okada, Yu Horibe, Toshiyuki Kanno, Takashi Motohashi, Tomoko Yamamoto, Yoji Nagashima, Tsutomu Tabata
発行年月	2025/11
概要	Uterine cervical lymphoepithelioma-like carcinoma (LELC) is a rare type of cervical squamous cell carcinoma (SCC). The present study describes a case of cervical LELC, including the cytological findings. A Japanese woman in her 40s was diagnosed with a high-grade squamous intraepithelial lesion (HSIL), suspected cytologically. The patient had previously tested positive for high-risk human papillomavirus (HPV). The cervical biopsy revealed findings that were indicative of HSIL/cervical intraepithelial neoplasia (CIN)2-3, and the patient was then referred to Tokyo Women's Medical University Hospital (Tokyo, Japan). A cervical cytological examination showed HSIL, and the presurgical cervical histological diagnosis was non-keratinizing SCC. Cervical conization was performed and the histopathological diagnosis was LELC. A cervical cytological specimen showed atypical cells with indistinct borders, enlarged round nuclei and a high nucleocytoplasmic ratio. Some cells had prominent nucleoli, and the tumor cells were intermingled with abundant neutrophils and lymphocytes. In addition, atypical squamous cells with orange G-philic cytoplasm and CIN-like atypical cells were observed, as well as clumps of atypical cells with thickened cytoplasm and a metaplastic appearance. The mechanism underlying the contributions of Epstein-Barr virus and/or HPV to the development of LELC is a topic for future investigation.
DOI	10.3892/mco.2025.2892
PMID	40901566