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ナカイ ヨウスケ
NAKAI Yousuke
中井 陽介 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Usefulness of an S-1 dosage formula for predicting adverse events in adjuvant chemotherapy for curatively resected pancreatic cancer: an exploratory analysis of the randomized clinical trial (JASPAC-01) |
| 掲載誌名 | 正式名：Journal of gastroenterology 略 称：J Gastroenterol ISSNコード：14355922/09441174 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 61(6),pp.821-830 |
| 著者・共著者 | ISHIGAKI Kazunaga, NAKAI Yosuke, KASHIWABARA Kousuke, FUJISHIRO Mitsuhiro, GOTOHDA Naoto, TOYAMA Hirochika, MAEDA Atsuyuki, SHIMIZU Yasuhiro, MIYAMOTO Atsushi, TAKAHASHI Amane, MORINAGA Soichiro, YANAGIBASHI Hiroo, GOTO Takuma, SAKUMA Yasunaru, TOMIKAWA Moriaki, OJIMA Hitoshi, OKAMURA Yukiyasu, FUKUTOMI Akira, BOKU Narikazu, UESAKA Katsuhiko |
| 担当区分 | 2nd著者 |
| 発行年月 | 2026/06 |
| 概要 | BACKGROUND:Adverse events (AEs) of S-1 are affected by renal function. A dosage formula for S-1 based on renal function and body surface area (BSA) has been developed, indicating the dose required to achieve a target blood concentration of 5-fluorouracil. This study aimed to explore the usefulness of this formula in adjuvant chemotherapy with S-1 for pancreatic cancer (PC).METHODS:In the JASPAC-01 trial, the actual initial dose of S-1 was calculated based on the BSA. Patients were divided into three groups by comparing the actual initial S-1 dose with the dose recommended by the S-1 dosage formula: underdose (UD), equal dose (ED), and overdose (OD). The recurrence rate, prognosis, and AEs in each group were evaluated.RESULTS:Among 187 eligible patients, 27 (14%), 43 (23%), and 117 (63%) patients were classified into the UD, ED, and OD groups. The incidence of all-grade and grade ≥ 3 anemia during the all-time periods were significantly higher in the OD group (94.9/18.8%) compared to the ED (93.0/4.7%) and UD (81.5/7.4%) groups (P = 0.04). In the UD/ED/OD groups, the planned adjuvant S-1 therapy for 6 months was completed in 77.8/72.1/70.9% (P = 0.51), whereas dose reduction was required in 0/14.0/22.2% (P = 0.01). The 5-year overall survival was slightly worse in OD group (41.9%) than those in the UD/ED groups (48.1/47.6%).CONCLUSIONS:In the adjuvant S-1 therapy for PC, AEs and dose reduction were more common in the OD group. The S-1 dosage formula may be useful for reducing AEs. |
| DOI | 10.1007/s00535-026-02413-5 |
| PMID | 41991754 |