キクヤマ　マサタカ   KIKUYAMA Masataka   菊山　正隆    所属   医学部 医学科（東京女子医科大学病院）    職種   特任准教授
論文種別	総説
言語種別	英語
査読の有無	査読あり
表題	Focal Pancreatic Parenchymal Atrophy: An Alternative Indicator for Early-Stage Pancreatic Cancer
掲載誌名	正式名：Visceral medicine 略　 称：Visc Med ISSNコード：22974725/22974725
掲載区分	国外
巻・号・頁	41(5),pp.280-285
著者・共著者	Masataka Kikuyama
担当区分	筆頭著者
発行年月	2025/10
概要	BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is characterized by a poor prognosis, with a high mortality rate often attributed to its late-stage diagnosis. Early detection remains paramount in improving survival outcomes for affected individuals.SUMMARY:The prognosis of PDAC can be significantly improved if the cancer is diagnosed at an early stage, specifically when it remains localized to the ductal epithelium. This early stage is commonly referred to as high-grade pancreatic intraepithelial neoplasia (HG-PanIN) or carcinoma in situ (CIS, stage 0). At this stage, metastasis has not yet occurred, offering the potential for more effective therapeutic interventions. Focal pancreatic parenchymal atrophy (FPPA) has emerged as a crucial radiological and pathological feature suggestive of HG-PanIN/CIS.KEY MESSAGE:Accurate identification of FPPA is critical for diagnosing HG-PanIN and CIS, both of which represent preinvasive stages of PDAC. Given the implications of early detection, serial pancreatic juice cytologic examination is recommended for patients exhibiting FPPA to facilitate timely diagnosis and intervention.
DOI	10.1159/000545847
PMID	40475864