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ホシノ ジュンイチ
Hoshino Junichi
星野 純一 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Kidney biopsy analysis of 14 cases of renal disease after unrelated cord blood transplantation. |
| 掲載誌名 | 正式名：BMC nephrology 略 称：BMC Nephrol ISSNコード：14712369/14712369 |
| 掲載区分 | 国外 |
| 巻・号・頁 | pp.online |
| 著者・共著者 | Mizuta Masato, Sawa Naoki, Suwabe Tatsuya, Oba Yuki, Sekine Akinari, Yamanouchi Masayuki, Mizuno Hiroki, Inoue Noriko, Tanaka Kiho, Hasegawa Eiko, Wake Atsushi, Hoshino Junichi, Kono Kei, Ohashi Kenichi, Yamaguchi Yutaka, Fukuda Makoto, Miyazono Motoaki, Wada Takehiko, Ubara Yoshifumi |
| 発行年月 | 2026/05/16 |
| 概要 | OBJECTIVE:To evaluate kidney biopsy findings to clarify renal disease in patients after hematopoietic stem cell transplantation (HSCT) using unrelated umbilical cord blood transplantation (UCBT).METHODS:We retrospectively examined 14 patients who underwent UCBT at Toranomon Hospital, Tokyo, Japan, from 2015 to 2023 and subsequently developed kidney injury requiring biopsy.RESULTS:At biopsy, median urinary protein was 0.57 g/day (IQR, 0.27-1.67), median serum creatinine was 1.97 mg/dL (IQR, 1.81-2.6), and median eGFR was 25.3 mL/min/1.73 m2 (IQR, 18.1-34.2). In 13 of 14 patients, mesangiolysis, glomerular basement membrane (GBM) duplication, and subendothelial widening without thrombi were observed-lesions defined as glomerular microangiopathy (GMA). Immunofluorescence and electron microscopy revealed no immune deposits typical of membranous nephropathy. Eleven patients showed distinctive arterial and arteriolar changes termed vascular microangiopathy. Nine exhibited severe interstitial fibrosis and tubular basement membrane duplication involving > 50% of the cortex. Human leukocyte antigen (HLA) incompatibility was found in 13 patients (92.9%) and ABO incompatibility in nine (64.2%). C4d positivity in glomeruli or peritubular capillaries was detected in 12 patients (85.7%).CONCLUSION:The coexistence of glomerular, vascular, and tubulointerstitial microangiopathic lesions was associated with mild proteinuria and renal dysfunction after UCBT. These findings suggest a chronic endothelial injury process distinct from classical thrombotic microangiopathy. |
| DOI | 10.1186/s12882-026-05034-5 |
| PMID | 42143299 |