ヤマグチ　シゲキ   YAMAGUCHI Shigeki   山口　茂樹    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Clinicopathological features and prognosis of metastatic tumors in the small bowel: a large multicenter analysis of the JSCCR database in Japan
掲載誌名	正式名：Journal of gastroenterology 略　 称：J Gastroenterol ISSNコード：14355922/09441174
掲載区分	国内
巻・号・頁	61(3),pp.266-278
著者・共著者	TSUBOI Akiyoshi,OKA Shiro,YAMADA Takeshi,MITSUI Keigo,YAMAMOTO Hironori,TAKAHASHI Keiichi,SHIOMI Akio,HOTTA Kinichi,TAKEUCHI Yoji,KUWAI Toshio,ISHIDA Fumio,KUDO Shin-Ei,SAITO Shoichi,UENO Masashi,SUNAMI Eiji,YAMANO Tomoki,ITABASHI Michio,OHTSUKA Kazuo,KINUGASA Yusuke,MATSUMOTO Takayuki,SUGAI Tamotsu,URAOKA Toshio,KURAHARA Koichi,YAMAGUCHI Shigeki,KATO Tomohiro,OKAJIMA Masazumi,KASHIDA Hiroshi,FUJITA Fumihiko,IKEMATSU Hiroaki,ITO Masaaki,ESAKI Motohiro,KAWAI Masaya,YAO Takashi,HAMADA Madoka,HORIMATSU Takahiro,KODA Keiji,FUKAI Yasumori,KOMORI Koji,SAITOH Yusuke,KANEMITSU Yukihide,TAKAMARU Hiroyuki,YAMADA Kazutaka,NOZAWA Hiroaki,TAKAYAMA Tetsuji,TOGASHI Kazutomo,SHINTO Eiji,TORISU Takehiro,TOYOSHIMA Akira,OHMIYA Naoki,KATO Takeshi,OTSUJI Eigo,NAGATA Shinji,HASHIGUCHI Yojiro,SUGIHARA Kenichi,AJIOKA Yoichi,TANAKA Shinji
発行年月	2026/03
概要	BACKGROUND:Owing to the rarity of metastatic tumors in the small bowel, their clinicopathological features, and prognostic factors remain poorly understood. This study aimed to clarify the clinicopathological features and factors associated with the prognosis of patients with small bowel metastasis from other organs in Japan.METHODS:We retrospectively examined 253 patients who were histopathologically diagnosed with small bowel metastases between January 2008 and December 2017 at multiple institutions in Japan. We identified the clinicopathological features of the condition and determined the factors associated with the prognosis of these patients.RESULTS:Obstructive symptoms were the most frequent clinical presentations (39% abdominal pain and 18% vomiting), while gastrointestinal bleeding was observed in 27% of patients. The diagnostic modalities included enteroscopy (33%), balloon-assisted enteroscopy (30%), and capsule endoscopy (13%). The most common primary tumor was lung cancer (38%), followed by colorectal cancer (18%), gastric cancer (9%), and malignant melanoma (6%). Surgical intervention, including tumor resection or bypass surgery, was performed in 79% of patients. The cumulative survival rates of patients at 12, 24, and 60 months were 49%, 36%, and 22%, respectively. Multivariate analysis identified surgery as a significant factor for improving overall survival (HR = 0.56, 95% CI 0.35-0.89, p = 0.01).CONCLUSIONS:The lung cancer is the most frequent primary tumor of metastatic tumors in the small bowel. Surgical intervention was associated with improved survival outcomes.
DOI	10.1007/s00535-025-02322-z
PMID	41251800