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ナカイ ヨウスケ
NAKAI Yousuke
中井 陽介 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 原著 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Encapsulation levels rather than elapsed time after the onset of acute pancreatitis are related to clinical outcomes of pancreatic walled-off necrosis |
| 掲載誌名 | 正式名：Endoscopy 略 称：Endoscopy ISSNコード：14388812/0013726X |
| 掲載区分 | 国外 |
| 巻・号・頁 | 57(12),pp.1355-1364 |
| 著者・共著者 | MARUTA Akinori,IWASHITA Takuji,SAITO Tomotaka,GONOI Wataru,YOSHIDA Kensaku,OMOTO Shunsuke,TAKENAKA Mamoru,TSUJIMAE Masahiroe,MASUDA Atsuhiro,HAMADA Tsuyoshi,UEMURA Shinya,OTA Shogo,SHIOMI Hideyuki,SUDA Kentaro,MATSUBARA Saburo,TAKAHASHI Sho,FUJISAWA Toshio,IWASA Yuhei,IWATA Keisuke,HAYASHI Nobuhiko,MUKAI Tsuyoshi,ISAYAMA Hiroyuki,YASUDA Ichiro,NAKAI Yosuke |
| 発行年月 | 2025/12 |
| 概要 | There is no consensus regarding the optimal timing of endoscopic ultrasound (EUS)-guided interventions for walled-off necrosis (WON) secondary to acute pancreatitis. Currently, intervention timing is primarily determined by the duration after the onset of acute pancreatitis, which potentially serves as a surrogate for fluid collection maturation. We hypothesized that the encapsulation status may be more strongly correlated with clinical outcomes.Between January 2010 and November 2020, 222 patients who underwent EUS-guided WON treatment at 11 centers of the WONDERFUL consortium were included. The patients were divided into two groups based on their encapsulation status at drainage (partial/no vs. complete). The clinical outcomes were compared between groups.Technical success rates were similar between the groups. Complete encapsulation was associated with a higher clinical success rate (88.1% vs. 52.2%; P<0.001). When patients were classified by both time elapsed and encapsulation status, the encapsulation status was more strongly associated with clinical success. Complete encapsulation was associated with a lower overall adverse event rate (22.7% vs. 39.1%; P=0.04). Overall mortality was significantly higher in the partial/no encapsulation group (34.8% vs. 3.4%; P <0.001). In multivariable analysis, the encapsulation status and diameter of the WON were identified as significant factors associated with clinical success.In patients undergoing EUS-guided WON treatment, the encapsulation status, rather than the time elapsed since disease onset, appeared to be more strongly associated with positive clinical outcomes. |
| DOI | 10.1055/a-2654-4317 |
| PMID | 40651464 |