ナカイ　ヨウスケ   NAKAI Yousuke   中井　陽介    所属   医学部 医学科（東京女子医科大学病院）    職種   教授・基幹分野長
論文種別	原著
言語種別	英語
査読の有無	査読あり
表題	Current treatment strategy for asymptomatic bile duct stones
掲載誌名	正式名：Expert review of gastroenterology & hepatology 略　 称：Expert Rev Gastroenterol Hepatol ISSNコード：17474132/17474124
掲載区分	国外
巻・号・頁	19(12),pp.1231-1239
著者・共著者	HAKUTA Ryunosuke, NAKABAYASHI Ryota, SHIMAMATSU Yutaka, OTSUKA Nao, TAKAYAMA Yukiko, KIKUYAMA Masataka, NAKAI Yosuke
担当区分	最終著者
発行年月	2025/12
概要	INTRODUCTION:Asymptomatic bile duct stones are increasingly diagnosed by imaging studies. Guidelines recommend endoscopic retrograde cholangiopancreatography (ERCP) for the treatment of bile duct stones, but evidence regarding short- and long-term outcomes of asymptomatic bile duct stones remains inadequate.AREA COVERED:This review summarized evidence about clinical outcomes and technical tips of ERCP for asymptomatic bile duct stones through a literature search of PubMed until March 2025. Long-term outcomes including cholangitis, cholecystitis, biliary pancreatitis, and spontaneous passage of bile duct stones among patients who selected the wait-and-see strategy were also summarized. According to the recent evidence of short- and long-term outcomes, we discussed the pros and cons of each treatment option and proposed a treatment strategy for asymptomatic bile duct stones.EXPERT OPINION:Despite guideline recommendations for endoscopic removal, ERCP for asymptomatic bile duct stones is associated with a high incidence of post-ERCP pancreatitis (PEP) and clinicians need to mitigate the risk of PEP by including administration of non-steroidal anti-inflammatory drugs, prophylactic pancreatic stent, or peri-procedural aggressive hydration. Considering the probability of spontaneous stone passage, the wait-and-see strategy might be a treatment option.
DOI	10.1080/17474124.2025.2588611
PMID	41211742