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ヒグチ リヨウタ
HIGUCHI Riyouta
樋口 亮太 所属 医学部 医学科（附属八千代医療センター） 職種 講師 |
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| 論文種別 | 症例報告 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Two Cases of Mixed Neuroendocrine Non-neuroendcrine Cell Neoplasms (MiNENs) of the Pancreas with Notable Molecular Pathological Features |
| 掲載誌名 | 正式名：Internal medicine 略 称：Intern Med ISSNコード：13497235/09182918 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 64(23),pp.3372-3379 |
| 著者・共著者 | SAITO Satomi, TAKAYAMA Yukiko, TANAKA Mariko, OTSUKA Nao, AKAO Junichi, TAHARA Junko, KIKUYAMA Masataka, TOKUSHIGE Katsutoshi, ITO Taito, FURUKAWA Toru, HIGUCHI Ryota, YAZAWA Takehisa, SHIMIZU Kyoko |
| 発行年月 | 2025/12 |
| 概要 | We herein report two cases of pancreatic mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs). Case A was a mixed ductal-neuroendocrine cell carcinoma with a KRAS mutation and loss of RB1 and SMAD4 expression. Case B was a mixed acinar-neuroendocrine cell carcinoma with wild-type KRAS and loss of p16 and SMAD4 expression. The expression of RB1 and ARID1A was also reduced. These results support the recently proposed classification of neuroendocrine carcinoma into ductal and acinar types based on molecular features, which may facilitate the understanding and development of specific treatments for this intractable tumor. |
| DOI | 10.2169/internalmedicine.5083-24 |
| PMID | 40467501 |