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ナカイ ヨウスケ
NAKAI Yousuke
中井 陽介 所属 医学部 医学科（東京女子医科大学病院） 職種 教授・基幹分野長 |
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| 論文種別 | 総説 |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | The 2024 diagnostic criteria for primary sclerosing cholangitis |
| 掲載誌名 | 正式名：Journal of gastroenterology 略 称：J Gastroenterol ISSNコード：14355922/09441174 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 60(10),pp.1221-1231 |
| 著者・共著者 | NAITOH Itaru,ISAYAMA Hiroyuki,AKAMATSU Nobuhisa,MIZUNO Suguru,FUJISAWA Toshio,NAKAMOTO Nobuhiro,NAKAI Yosuke,UMETSU Shuichiro,SUZUKI Mitsuyoshi,YAGI Shintaro,HAGA Hironori,NOTOHARA Kenji,SANO Katsuhiro,TAZUMA Susumu,NAKAZAWA Takahiro,TANAKA Atsushi |
| 発行年月 | 2025/10 |
| 概要 | Primary sclerosing cholangitis (PSC) is an idiopathic chronic cholestatic disease with a poor prognosis. As there were no specific biomarkers for diagnosing PSC, we developed diagnostic criteria in 2016 based on cholangiography and elevated biliary enzymes. Novel findings and knowledge have subsequently accumulated, and we now propose the 2024 diagnostic criteria, to overcome several limitations of the 2016 diagnostic criteria. The Intractable Hepato-Biliary Diseases Study Group in Japan of the Committee of Research on Measures for Intractable Diseases established a working group consisting of experts in PSC comprising gastroenterologists, endoscopists, hepatologists, liver-transplant surgeons, pediatric hepatologists, pathologists, and radiologists. This working group proposed the 2024 diagnostic criteria after several discussions and public hearings. There are additional diagnostic targets; small duct PSC, pediatric PSC, and PSC recurrence following liver transplantation differ from the 2016 diagnostic criteria, which were for diagnosing large duct PSC in adults. The 2024 diagnostic criteria facilitate the use of magnetic resonance cholangiography in addition to endoscopic retrograde cholangiography in imaging, and incorporate gamma-glutamyl transferase for evaluating cholestasis to diagnose pediatric patients. Furthermore, PSC recurrence following liver transplantation can be diagnosed based on a liver biopsy and characteristic biliary findings. We hope that the 2024 diagnostic criteria will help not only hepatologists treating adults but also general physicians, pediatric hepatologists, and liver-transplant surgeons who manage patients with various forms of PSC. |
| DOI | 10.1007/s00535-025-02265-5 |
| PMID | 40504416 |